Document 0530
 DOCN  M9480530
 TI    A longitudinal study of cytomegalovirus infection in human
       immunodeficiency virus type 1-seropositive homosexual men: molecular
       epidemiology and association with disease progression.
 DT    9410
 AU    Leach CT; Detels R; Hennessey K; Liu Z; Visscher BR; Dudley JP; Cherry
       JD; UCLA School of Public Health.
 SO    J Infect Dis. 1994 Aug;170(2):293-8. Unique Identifier : AIDSLINE
       MED/94308592
 AB    Cytomegalovirus (CMV) isolates from 234 asymptomatic human
       immunodeficiency type 1 (HIV-1)-positive men were analyzed for molecular
       relatedness using junctional hybridization. Of isolates shed
       simultaneously at two or more body sites, 36% from 22 men were
       different. Of 180 isolates collected from 67 men over 15 months,
       different strains were isolated serially from 27 men (40%), most from
       semen. After follow-up of 58 months (mean), the relative hazard of HIV
       infection progressing to AIDS was 1.8 (95% confidence interval [CI],
       0.9-3.7) for men shedding the same strain of CMV and 3.0 (95% CI,
       1.4-6.1) for men shedding different strains compared with men not
       shedding CMV in semen. The prevalence of CMV-specific IgM was higher in
       men shedding different versus same CMV strains (32% vs. 18%; P = .244).
       Thus, presence of multiple CMV strains in HIV-1-positive homosexual men
       is associated with progression to AIDS, possibly via activation of
       HIV-1-infected CD4 cells.
 DE    Cohort Studies  Cytomegalovirus/CLASSIFICATION/*GENETICS/ISOLATION &
       PURIF  Cytomegalovirus Infections/EPIDEMIOLOGY/*ETIOLOGY/MICROBIOLOGY
       DNA, Viral/ANALYSIS  Homosexuality  Human  HIV
       Seropositivity/*COMPLICATIONS  *HIV-1  Longitudinal Studies  Male
       Nucleic Acid Hybridization  Prevalence  Restriction Mapping
       Semen/MICROBIOLOGY  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE
       MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).